Cytotoxicity of new flavonoid compound isolated from Farsetia aegyptia

Medicinal herbs are also significant source of synthetic and herbal drugs. So far, pharmaceutical companies have screened more than 25,000 plants for anti-cancer drugs. So we done to discover the anticancer activity of the phenolic compound isolated from terrestrial Egyptian plants, the EtOH extract of the aerial parts of the Egyptian medicinal plant farsetia aegyptia (Forssk.) Boiss. was in vitro investigated for cytotoxicity against HCT116, HepG2 and MCF-7 cell lines, and resulted with IC50 = 4.65, 12.60 and 17.90 μg/ml, respectively. Doxorubicin (+ve control) showed in vitro cytotoxic activity with IC50 = 3.64, 4.57 and 2.97 μg/ml, respectively, The phenolic-rich fraction of the EtOH extract was subjected to further fractionation, which led to the isolation of new flavonoid (kampferol 7-8 diglucoside); low polar fractions revealed the isolation of other known compound which identified, according to its’ spectral data and comparison with the literature, Furthermore new flavonoid compound give high cytotoxicty against Hela and MCF-7 cell lines,also cytotoxity of the isolated known compounds were studied